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Nathan Goodyear

Which Patients Do Not Require a GH Stimulation Test for the Diagnosis of Adult GH Defic... - 0 views

press.endocrine.org/...jcem.87.2.8216

HGH GH human growth hormone growth hormone IGF-1

shared by Nathan Goodyear on 04 Nov 14 - No Cached
  • Four studies have reported that the probability of GHD (peak GH criteria ranging from < 2.3 to < 5 μg/liter) in patients with three to four PHDs ranges from 91% to 100%
  • 95% accuracy by the presence of either three or more PHDs or a serum IGF-I concentration less than 84 μg/lite
  • adult GHD could be predicted with 95% accuracy by the presence of either three or four PHDs or a serum IGF-I concentration less than 84 μg/liter
  • ...5 more annotations...
  • Hypopituitary adults with GHD have been reported to have normal serum IGF-I levels in 37–70% of patients in various studies (5, 9, 18, 21, 22). This is owing in part to the fact that multiple factors regulate serum IGF-I concentrations including nutritional status; hepatic and renal function; and circulating concentrations of thyroid hormone, androgens, and estrogens
  • changes in concentrations of IGF-binding proteins (IGFBPs) influence the total concentration of IGF-I in plasma
  • Among patients with an IGF-I sd score above −1 in the present study, 46% had a peak GH less than 2.5 μg/liter and 67% had a peak GH less than 5 μg/liter.
  • In summary, adult GHD can be predicted with 95% accuracy by the presence of either three or four PHDs or a serum IGF-I concentration less than 84 μg/liter
  • We propose that adult patients with three or four PHDs (three or four of the following deficiencies: TSH, ACTH, gonadotropins [LH and/or FSH], and AVP [central diabetes insipidus]) do not require a GH stimulation test to make the diagnosis of adult GHD
  • Nathan Goodyear on 04 Nov 14
     
    Insulin Tolerance Test is the gold standard for HGH diagnosis, but this an unpopular test do to long list of side effects.  This study finds a 95% accuracy for IGF-1 less than 84 with 3 or more coexisting pituitary hormone deficiencies.
Nathan Goodyear

Low-Fat High-Fiber Diet Decreased Serum and Urine Androgens in Men: The Journal of Clin... - 0 views

press.endocrine.org/...jc.2004-1530

diet nutrition Testosterone androgens men hormones male hormones

shared by Nathan Goodyear on 21 Sep 16 - No Cached
  • Nathan Goodyear on 21 Sep 16
     
    lower fat, higher fiber diets result in 12% reduction in circulating male hormones
Nathan Goodyear

Dietary factors and luteal phase deficiency in healthy eumenorrheic women - 0 views

www.ncbi.nlm.nih.gov/...PMC4507331

hormones female hormones diet nutrition progesterone estrogen women

shared by Nathan Goodyear on 15 Feb 17 - No Cached
  • Nathan Goodyear on 15 Feb 17
     
    great read and review of diet and hormones in cycling women.
Nathan Goodyear

Human Saliva as a Diagnostic Specimen - 1 views

jn.nutrition.org/...1621S.short

saliva testing serum hormones hormone BHRT

shared by Nathan Goodyear on 27 Nov 11 - No Cached
  • Nathan Goodyear on 27 Nov 11
     
    saliva testing of hormones shown to be a good tool for diagnosis and provides information not obtainable from blood
Nathan Goodyear

Serum Sex Steroids in Premenopausal Women and Breast Cancer Risk Within the European Pr... - 0 views

jnci.oxfordjournals.org/...755.long

serum hormone hormones Testosterone progesterone estrogen estradiol breast cancer women female

shared by Nathan Goodyear on 21 Mar 14 - No Cached
  • Nathan Goodyear on 21 Mar 14
     
    Study finds that elevated serum Testosterone and androstenedione is associated with an increase risk of breast cancer.  This EPIC study looked at serum hormones in premenopausal women.  This study also found an association with increased breast cancer and low serum progesterone in women.  This was also found in the ORDET study.  This study did not find a link with estrogen.  These are endogenous levels.  Does this translate to exogenous? This theory of elevated androgens and breast cancer was first proposed by Grattarola.
Nathan Goodyear

Thieme E-Journals - Hormone and Metabolic Research / Abstract - 0 views

www.thieme-connect.com/...DOI

very-low-calorie diet calorie restriction nutrition low T low Testosterone male hormones Testosterone men male hormone hormones

shared by Nathan Goodyear on 27 Oct 14 - No Cached
  • Nathan Goodyear on 27 Oct 14
     
    Very low calorie diet over 12 weeks increased endogenous Testosterone levels in men via improved Testicular production and reduced aromatase activity due to decreased adipose tissue.
Nathan Goodyear

Annals of Internal Medicine | Are Organic Foods Safer or Healthier Than Conventional Al... - 0 views

annals.org/article.aspx

organic nutrition foods food xenoestrogens toxins pesticides

shared by Nathan Goodyear on 04 Sep 12 - No Cached
  • Nathan Goodyear on 04 Sep 12
     
    study claims that organic foods provide no additional nutritional value above non-organic foods.  Problem is, that is not the reason to push organic.  Elimination of xenoestrogens, hormones, and other toxins is.
Nathan Goodyear

Fifty-two-week treatment with diet and exercise plus transdermal te... - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19578132

low t low testosterone Testosterone diabetes metabolic syndrome insulin resistance adkiponectin CRP hsCRP men male hormone hormones diet nutrition exercise HgbA1c

shared by Nathan Goodyear on 02 Mar 15 - No Cached
  • Nathan Goodyear on 02 Mar 15
     
    This article finds that Testosterone transdermal therapy addition to Diet and exercise improved glycemic control and reversed Metabolic Syndrome in men with low T and type II Diabetes.  This article really highlights the proper approach to therapy: combined nutrition, exercise, and Testosterone therapy, when indicated, for men with Metabolic Syndrome and/or Diabetes.  A reduction in IR, adiponectin and hsCRP was observed.
Nathan Goodyear

Diet-hormone interactions: Protein/carbohydrate ratio alters reciprocally the plasma le... - 0 views

www.sciencedirect.com/...0024320587900865

nutrition diet carbohydrates fiber protein Testosterone men hormones male hormones cortisol

shared by Nathan Goodyear on 21 Sep 16 - No Cached
  • Nathan Goodyear on 21 Sep 16
     
    small study, but complex carbs found to increase Testosterone more than high protein diet.  That goes against most marketing.  In contrast, cortisol was the opposite.
Nathan Goodyear

Diet and Sex Hormone-Binding Globulin: The Journal of Clinical Endocrinology & Metaboli... - 0 views

press.endocrine.org/...jcem.85.1.6291

diet nutrition Testosterone SHBG low T low Testosterone hormones male hormones men

shared by Nathan Goodyear on 21 Sep 16 - No Cached
  • Nathan Goodyear on 21 Sep 16
     
    diets lower in protein, result in decreases SHBG and thus decreased bioavailable Testosterone.
Nathan Goodyear

Effect of low-fat diet on female sex hormone levels. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...3480374

nutrition diet low fat diet hormones female hormones estrogen Testosterone

shared by Nathan Goodyear on 15 Feb 17 - No Cached
  • Nathan Goodyear on 15 Feb 17
     
    low fat diet drops estrogen levels precipitously in women.  It also dropped Testosterone levels.
Nathan Goodyear

Nutrition Journal | Full text | Red wine and components flavonoids inhibit UGT2B17 in v... - 0 views

www.nutritionj.com/...67

red wine wine testosterone hormone hormones male nutrition

shared by Nathan Goodyear on 08 Jan 13 - No Cached
  • Nathan Goodyear on 08 Jan 13
     
    Red wine to increase testosterone levels?  According to this study, yes.  How?  By interfering with the elimination through the UGT2B17 detoxification pathway.   Downside of this study is that this is in vitro and not in vivo.
Nathan Goodyear

Nutrition & Metabolism | Full text | Fructose, insulin resistance, and metabolic dyslip... - 0 views

www.nutritionandmetabolism.com/...5

fructose metabolic syndrome metabolic syndrome insulin resistance obesity nutrition metabolism

shared by Nathan Goodyear on 16 Sep 13 - Cached
  • For thousands of years humans consumed fructose amounting to 16–20 grams per day
  • daily consumptions amounting to 85–100 grams of fructose per day
  • Of key importance is the ability of fructose to by-pass the main regulatory step of glycolysis, the conversion of glucose-6-phosphate to fructose 1,6-bisphosphate, controlled by phosphofructokinase
  • ...29 more annotations...
  • Thus, while glucose metabolism is negatively regulated by phosphofructokinase, fructose can continuously enter the glycolytic pathway. Therefore, fructose can uncontrollably produce glucose, glycogen, lactate, and pyruvate, providing both the glycerol and acyl portions of acyl-glycerol molecules. These particular substrates, and the resultant excess energy flux due to unregulated fructose metabolism, will promote the over-production of TG (reviewed in [53]).
  • Glycemic excursions and insulin responses were reduced by 66% and 65%, respectively, in the fructose-consuming subjects
  • reduction in circulating leptin both in the short and long-term as well as a 30% reduction in ghrelin (an orexigenic gastroenteric hormone) in the fructose group compared to the glucose group.
  • A prolonged elevation of TG was also seen in the high fructose subjects
  • Both fat and fructose consumption usually results in low leptin concentrations which, in turn, leads to overeating in populations consuming energy from these particular macronutrients
  • Chronic fructose consumption reduces adiponectin responses, contributing to insulin resistance
  • A definite relationship has also been found between metabolic syndrome and hyperhomocysteinemia
  • the liver takes up dietary fructose rapidly where it can be converted to glycerol-3-phosphate. This substrate favours esterification of unbound FFA to form the TG
  • Fructose stimulates TG production, but impairs removal, creating the known dyslipidemic profile
  • the effects of fructose in promoting TG synthesis are independent of insulinemia
  • Although fructose does not appear to acutely increase insulin levels, chronic exposure seems to indirectly cause hyperinsulinemia and obesity through other mechanisms. One proposed mechanism involves GLUT5
  • If FFA are not removed from tissues, as occurs in fructose fed insulin resistant models, there is an increased energy and FFA flux that leads to the increased secretion of TG
  • In these scenarios, where there is excess hepatic fatty acid uptake, synthesis and secretion, 'input' of fats in the liver exceed 'outputs', and hepatic steatosis occurs
  • Carbohydrate induced hypertriglycerolemia results from a combination of both TG overproduction, and inadequate TG clearance
  • fructose-induced metabolic dyslipidemia is usually accompanied by whole body insulin resistance [100] and reduced hepatic insulin sensitivity
  • Excess VLDL secretion has been shown to deliver increased fatty acids and TG to muscle and other tissues, further inducing insulin resistance
  • the metabolic effects of fructose occur through rapid utilization in the liver due to the bypassing of the regulatory phosphofructokinase step in glycolysis. This in turn causes activation of pyruvate dehydrogenase, and subsequent modifications favoring esterification of fatty acids, again leading to increased VLDL secretion
  • High fructose diets can have a hypertriglyceridemic and pro-oxidant effect
  • Oxidative stress has often been implicated in the pathology of insulin resistance induced by fructose feeding
  • Administration of alpha-lipoic acid (LA) has been shown to prevent these changes, and improve insulin sensitivity
  • LA treatment also prevents several deleterious effects of fructose feeding: the increases in cholesterol, TG, activity of lipogenic enzymes, and VLDL secretion
  • Fructose has also been implicated in reducing PPARα levels
  • PPARα is a ligand activated nuclear hormone receptor that is responsible for inducing mitochondrial and peroxisomal β-oxidation
  • decreased PPARα expression can result in reduced oxidation, leading to cellular lipid accumulation
  • fructose diets altered the structure and function of VLDL particles causing and increase in the TG: protein ratio
  • LDL particle size has been found to be inversely related to TG concentration
  • therefore the higher TG results in a smaller, denser, more atherogenic LDL particle, which contributes to the morbidity of the metabolic disorders associated with insulin resistance
  • High fructose, which stimulates VLDL secretion, may initiate the cycle that results in metabolic syndrome long before type 2 diabetes and obesity develop
  • A high flux of fructose to the liver, the main organ capable of metabolizing this simple carbohydrate, disturbs normal hepatic carbohydrate metabolism leading to two major consequences (Figure 2): perturbations in glucose metabolism and glucose uptake pathways, and a significantly enhanced rate of de novo lipogenesis and TG synthesis, driven by the high flux of glycerol and acyl portions of TG molecules coming from fructose catabolism
  • Nathan Goodyear on 16 Sep 13
     
    Fructose and metabolic syndrome.  Good discussion of the impact of high fructose intake and metabolic dysfunction.  This study also does a great job of highlighting the historical change of fructose intake.
Nathan Goodyear

Use of amino acids as growth hormone-relea... [Nutrition. 2002 Jul-Aug] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12093449

GH growth hormone HGH arginine lysine ornithine nutrition

shared by Nathan Goodyear on 30 Jun 14 - No Cached
  • Nathan Goodyear on 30 Jun 14
     
    Study finds that amino acid supplementation does not increase GH release.
Nathan Goodyear

Focus on metabolic and nutritional corre... [Arch Gynecol Obstet. 2014] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...25200687

PCOS polycystic ovarian syndrome polycystic ovary syndrome nutrition diet lifestyle women female hormone hormones

shared by Nathan Goodyear on 12 Sep 14 - No Cached
  • Nathan Goodyear on 12 Sep 14
     
    Dietary lifestyle changes still prove to be the most effective treatment strategy for women with PCOS.
Nathan Goodyear

Dietary glycine and blood pressure: the International Study on Macro/Micronutrients and... - 0 views

ajcn.nutrition.org/...136.abstract

blood pressure glycine amino acids

shared by Nathan Goodyear on 26 Jun 13 - No Cached
  • Nathan Goodyear on 26 Jun 13
     
    This study links glycine to increased blood pressure.  However, meat is the primary source of glycine. So, if the meat is loaded with omega-6, hormones...these will be the source of the inflammation and resultant increase in blood pressure, not the glycine.  One must read these studies closely.  No conclusion can be made from this study.
Nathan Goodyear

Salivary cortisol and testosterone responses to resistance and plyometric exercise in 1... - 0 views

www.nrcresearchpress.com/...apnm-2015-0668

resistance training exercise testosterone cortisol hormones male hormones

shared by Nathan Goodyear on 16 May 16 - No Cached
  • Nathan Goodyear on 16 May 16
     
    Study of 12-14 y/o boys found increased Testosterone after resistance training and plyometric exercise.  Cortisol did increase after plyometric, but not resistance exercise.
Nathan Goodyear

Testosterone decreases after ingestion of sugar (glucose) | Endocrine Society - 0 views

www.endocrine.org/...decreasesafteringestionofsugar

glucose sugar diet nutrition Testosterone male hormones men hormones low T low Testosterone

shared by Nathan Goodyear on 19 Sep 16 - No Cached
  • Nathan Goodyear on 19 Sep 16
     
    sugar intake can decrease Testosterone levels by as much as 25% in men.
Nathan Goodyear

Effect of meal fat content on salivary testosterone and cortisol levels in healthy fema... - 0 views

www.endocrine-abstracts.org/...ea0010p75.htm

Testosterone nutrition diet fat low T low Testosterone hormones saliva salivary hormones

shared by Nathan Goodyear on 19 Sep 16 - No Cached
  • Nathan Goodyear on 19 Sep 16
     
    higher fat diet found to increase cortisol and Testosterone levels post meal in health women.  The effect was first seen early after lunch (30 minutes).
Nathan Goodyear

Effect of a vegetarian diet and dexamethasone on plasma prolactin, testosterone and deh... - 0 views

www.sciencedirect.com/...S0304383579800543

diet nutrition Testosterone men male hormones hormones prolactin vegetarian

shared by Nathan Goodyear on 21 Sep 16 - No Cached
  • Nathan Goodyear on 21 Sep 16
     
    Older study finds a vegetarian diet causes a decrease in prolactin and Testosterone in men.
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